Development and Characterization of Paliperidone Loaded Nanostructured Lipid Carrier

Abstract: Background: Paliperidone is indicated for the treatment of schizophrenia. It has an absolute oral bioavailability about 28% as it poorly soluble in water and also undergoes hepatic first-pass metabolism. Objectives: The purpose present study to improve solubility, vitro paliperidone by formulating nanostructured lipid carrier (NLC). Materials Methods: High shear homogenization followed ultrasonication technique was used preparation NLCs loaded with Paliperidone, were prepared varying weight solid liquid different ratios. Lyophilization selected NLC carried out further its stability. Results: Glyceryl monostearate, Linoleic acid, Tween 80 20 (2:1) lipid, surfactant correspondingly development NLC. formulation F5 best exhibited lowest particle size, PDI stable zeta potential drug release 12 hr. Selected lyophilized stability using cryoprotectants vis-à-vis sucrose, sorbitol aerosol. Lyophilized showed a slight increase size. DSC P-XRD revealed molecular dispersion matrix. Conclusion: Hence approach improving in-vitro bioavailability. Keywords: homogenization, Ultrasonication, Lyophilization, Bioavailability, Stability.